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Overcoming ADC Challenges of Toxicity and Drug Resistance with a Granzyme B Payload

Overcoming ADC Challenges of Toxicity and Drug Resistance with a Granzyme B Payload

AbBC Therapeutics’ Dr Claire Thuning-Roberson lays out the challenges hindering the current class of ADCs, and how utilizing Granzyme B, a serine protease enzyme in the immune system, can address or alleviate those challenges. 

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Featured Editorial

Could In Vivo CAR-T Cell Therapy Replace Ex Vivo?

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Report: Cancer Research Institute's 2025 Cancer Immunotherapy Insights and Impact

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IO360º Convenes Technology and Solution Providers to Address Key Capabilities to Advance IO Drug Development

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MSK on Adding ADCs to Checkpoint Blockade for Bladder Cancer Patients

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Editorial

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Conference Forum Joins Fierce Life Sciences
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Shining a Light on the Immune System to Inform Medicine Development at GSK
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Immuno-Oncology 360º Announces 2026 Featured Speakers and Key Topics for the 12th Annual Meeting in Boston
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Developing Nonactivated CAR T Therapy for Greater Persistence, Reduced Exhaustion and Enhanced In Vivo Expansion
Whole-Body Molecular Imaging’s Impact on Understanding Tumor Response and Advancing Immuno-Oncology (IO) Drug Development

Whole-Body Molecular Imaging’s Impact on Understanding Tumor Response and Advancing Immuno-Oncology (IO) Drug Development

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Going After Immune Resistance and Metastases in Cancer Using RNA-Based Therapeutics

Going After Immune Resistance and Metastases in Cancer Using RNA-Based Therapeutics
Staying Passionate about IO’s Potential and Investing in Biotechs Addressing IO’s Toughest Challenges

Staying Passionate about IO’s Potential and Investing in Biotechs Addressing IO’s Toughest Challenges
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GSK’s Head of Precision Medicine on Biomarker Focus and the Use of Next-Generation Technologies
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T Cell Engagers, Moving Beyond Pembrolizumab, and Medicine Development for Future Patients, with Roche's Ashley Lakner
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Pediatric Oncology’s Changing Regulatory Landscape and How to Navigate It
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How Merck Research Labs Is Evolving its Global Clinical Supply to Meet the Demands of Newer Modalities
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Leveraging a US-Chinese Biotech Collaboration to Develop a PD-1/VEGF Bispecific Antibody
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Immuno-Oncology 360° 2025 Recap
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Developing Checkpoint Inhibitors for Patients Who Don’t Respond to PD-1/CTLA-4
Breaking Down Silos and Applying Automation to Turn Imaging Analysis on Its Head

Breaking Down Silos and Applying Automation to Turn Imaging Analysis on Its Head

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Women Leadership in Immuno-Oncology Annual Profile Series: 2025 Edition

Women Leadership in Immuno-Oncology Annual Profile Series: 2025 Edition
A Systemic Approach to Oncolytic Viruses for Treating Solid Tumors

A Systemic Approach to Oncolytic Viruses for Treating Solid Tumors
AbbVie’s Head of Oncology Precision Medicine on the Exciting Developments in Immuno-Oncology

AbbVie’s Head of Oncology Precision Medicine on the Exciting Developments in Immuno-Oncology
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How Immatics’ VP of Late-Stage Development Navigating the Transition from Early Development for a TCR-T Therapy
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How AstraZeneca Approaches Finding New Treatments for Patients with Multiple Myeloma
Making Cell and Gene Therapy Accessible for Medicaid Enrollees: White Paper

Making Cell and Gene Therapy Accessible for Medicaid Enrollees: White Paper
Harnessing the Power of Cytokines with a Conditionally Active Agent

Harnessing the Power of Cytokines with a Conditionally Active Agent
Creating In Vivo Protein Factories at Be Bio for a New Class of Biologics

Creating In Vivo Protein Factories at Be Bio for a New Class of Biologics
Coherus Chief Development Officer on Next Steps in Toripalimab Drug Development

Coherus Chief Development Officer on Next Steps in Toripalimab Drug Development
Morgan Stanley’s Co-Head of Healthcare Equity Capital Markets on What IO Biotechs Can Expect in 2025

Morgan Stanley’s Co-Head of Healthcare Equity Capital Markets on What IO Biotechs Can Expect in 2025
The Current State of the IO Fundraising Landscape from a Long-Time Biotech Investor

The Current State of the IO Fundraising Landscape from a Long-Time Biotech Investor
The State of Cell Therapy Manufacturing with the Rise of Approved Products

The State of Cell Therapy Manufacturing with the Rise of Approved Products
The Conference Forum Sees Record Growth in Attendees Across 2024 Events, Bringing Together Leaders in Medicine Development

The Conference Forum Sees Record Growth in Attendees Across 2024 Events, Bringing Together Leaders in Medicine Development
Improving CAR T Therapies with Better Patient Access at Novartis

Improving CAR T Therapies with Better Patient Access at Novartis
How Circulating Tumor DNA is Being Evaluated as a Potential Endpoint for Immuno-Oncology

How Circulating Tumor DNA is Being Evaluated as a Potential Endpoint for Immuno-Oncology
Key Skills and Career Moves on the Journey to Becoming a CEO, with Fred Hassan

Key Skills and Career Moves on the Journey to Becoming a CEO, with Fred Hassan
Why Some People Respond to IO, and Others Don’t

Why Some People Respond to IO, and Others Don’t
What Immuno-Oncologists Need to Know About Radiopharmaceuticals

What Immuno-Oncologists Need to Know About Radiopharmaceuticals
Transforming Autoimmune Patient Outcomes with CAR T

Transforming Autoimmune Patient Outcomes with CAR T
Practical Considerations of Response Assessment in Neuro-Oncology 2.0 for Clinical Trials

Practical Considerations of Response Assessment in Neuro-Oncology 2.0 for Clinical Trials

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Unlocking Precision Medicine, Tumor Heterogeneity and Patient Monitoring with Advances in Imaging

Unlocking Precision Medicine, Tumor Heterogeneity and Patient Monitoring with Advances in Imaging
Developing a Molecule to Help Patients Respond to Immunotherapy

Developing a Molecule to Help Patients Respond to Immunotherapy
A New Approach to Cancer Vaccines, With a Focus on T Cells

A New Approach to Cancer Vaccines, With a Focus on T Cells
IO360º 2024 – Utilization of IO Agents in Adjuvant Disease and Update on Adjuvant Vaccine Studies

IO360º 2024 – Utilization of IO Agents in Adjuvant Disease and Update on Adjuvant Vaccine Studies
Providing IO Options for Breast Cancer Patients

Providing IO Options for Breast Cancer Patients
Dr Roy Baynes on Strategy Development for Keytruda

Dr Roy Baynes on Strategy Development for Keytruda
Embracing the Role of the Chief Medical Officer at Legend Biotech

Embracing the Role of the Chief Medical Officer at Legend Biotech
How Circular RNA is Enabling In Vivo CAR Delivery and Reducing Patient Treatment Burden

How Circular RNA is Enabling In Vivo CAR Delivery and Reducing Patient Treatment Burden
RNA Therapeutics for Metastatic Triple-Negative Breast Cancer and Pancreatic Cancer

RNA Therapeutics for Metastatic Triple-Negative Breast Cancer and Pancreatic Cancer
Moffitt Cancer Center CEO Dr Patrick Hwu on CAR T, TILs and Tracking Patient Outcomes

Moffitt Cancer Center CEO Dr Patrick Hwu on CAR T, TILs and Tracking Patient Outcomes
The Role of Generative AI in Making Better Immuno-Oncology Therapeutics

The Role of Generative AI in Making Better Immuno-Oncology Therapeutics
Pushing IO and Cell Therapy Further at Astellas

Pushing IO and Cell Therapy Further at Astellas
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When Immunotherapy Offers the Chance for Life and Family After Cancer Diagnosis

When Immunotherapy Offers the Chance for Life and Family After Cancer Diagnosis
Getting Cell Therapies into Solid Tumors and Avoiding Immune Suppression

Getting Cell Therapies into Solid Tumors and Avoiding Immune Suppression
The First-Time CEO Using a New Paradigm to Attack Metastatic Cancer

The First-Time CEO Using a New Paradigm to Attack Metastatic Cancer
The Biotech Analyst Helping Immuno-Oncology Investors Make Better Decisions

The Biotech Analyst Helping Immuno-Oncology Investors Make Better Decisions
How to Make Tumors More Targetable, Using the Tumor Microenvironment

How to Make Tumors More Targetable, Using the Tumor Microenvironment
Carl June and Daniel Chen on the Future of CAR-T, Cell Therapy, T-Cell Engagers and Synthetic Immunity

Carl June and Daniel Chen on the Future of CAR-T, Cell Therapy, T-Cell Engagers and Synthetic Immunity
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Using Innate Immunity to Create a New Way of Going After Cancer
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The Regulatory Affairs Leader Helping to Advance Novel Therapies and Establish New Surrogate Endpoints

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Giving New Hope to Myeloma Patients and Working on the Next Generation of Cell Therapies
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Building a Biotech from a Technology That Turns Target Identification on its Head

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Blocking GDF-15 to Conquer Immunosupression and Enhance Treatment Efficacy

Blocking GDF-15 to Conquer Immunosupression and Enhance Treatment Efficacy
Dr Carolyn Bertozzi Shares Her Award-Winning Work in IO and Her Hope for Greater Diversity in the Field

Dr Carolyn Bertozzi Shares Her Award-Winning Work in IO and Her Hope for Greater Diversity in the Field
Directing AstraZeneca's Oncology Strategies

Directing AstraZeneca's Oncology Strategies
UPenn's Dr Bruce Levine on Advancements in Cell Therapy Manufacturing

UPenn's Dr Bruce Levine on Advancements in Cell Therapy Manufacturing
How the NYU Genome Center is Making Better Cell Therapies

How the NYU Genome Center is Making Better Cell Therapies
Developing MSK's First Gene Transfer Clinic, Expediting Cell Therapy

Developing MSK's First Gene Transfer Clinic, Expediting Cell Therapy
MGH Cancer Center Breaks Down the T Cell to Better Understand Immuno-Oncology

MGH Cancer Center Breaks Down the T Cell to Better Understand Immuno-Oncology
New Approaches to Treat Brain Cancers Out of City of Hope

New Approaches to Treat Brain Cancers Out of City of Hope
Leading Immune Checkpoint Therapy Trials in NSCLC, at MD Anderson

Leading Immune Checkpoint Therapy Trials in NSCLC, at MD Anderson
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Merck's Mission for More Effective Breast Cancer Immunotherapy Treatments
BMS on Managing IO Operations and Sparking Joy for Science in Young People

BMS on Managing IO Operations and Sparking Joy for Science in Young People
Combining Natural Killer Cells and Synthetic Biology to Fight Solid Tumor Cancers

Combining Natural Killer Cells and Synthetic Biology to Fight Solid Tumor Cancers
Takeda’s Approach to Translational Medicine in Immuno-Oncology

Takeda’s Approach to Translational Medicine in Immuno-Oncology
Archive Highlight: How Genomics Is Advancing the Next Generation of IO at the Cleveland Clinic

Archive Highlight: How Genomics Is Advancing the Next Generation of IO at the Cleveland Clinic
Dr Arie Belldegrun on Staying Ahead of the Scientific Curve

Dr Arie Belldegrun on Staying Ahead of the Scientific Curve

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